Sep 30, 2023

Alnylam Q3 2023 Earnings Report

Alnylam reported strong commercial results and pipeline advancements, but was disappointed by the FDA's Complete Response Letter for ONPATTRO.

Key Takeaways

Alnylam Pharmaceuticals reported a 35% year-over-year increase in net product revenues, driven by the successful launch of AMVUTTRA. The company is on track to report topline results from the HELIOS-B Phase 3 study in early 2024 and reported positive topline results from the KARDIA-1 Phase 2 study of Zilebesiran.

Achieved global net product revenues of $313 million, representing 35% year-over-year growth.

Received Complete Response Letter from U.S. FDA for supplemental New Drug Application for Patisiran for the treatment of the Cardiomyopathy of ATTR Amyloidosis.

Company remains on track to report topline results from HELIOS-B Phase 3 study in early 2024.

Reported positive topline results from KARDIA-1 Phase 2 study of Zilebesiran.

Total Revenue
$751M
Previous year: $264M
+184.0%
EPS
$1.74
Previous year: -$1.58
-210.1%
Gross Profit
$666M
Previous year: $223M
+198.5%
Cash and Equivalents
$1.03B
Previous year: $1.07B
-3.7%
Free Cash Flow
$342M
Previous year: -$132M
-359.7%
Total Assets
$3.84B
Previous year: $3.54B
+8.6%

Alnylam

Alnylam

Alnylam Revenue by Segment

Forward Guidance

Alnylam updated its 2023 guidance for revenues from collaborations and royalties to $575 million to $625 million and reiterated its 2023 guidance for combined net product revenues of $1,200 million to $1,285 million.

Revenue & Expenses

Visualization of income flow from segment revenue to net income