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Dec 31, 2021

Allovir Q4 2021 Earnings Report

Reported full-year financial results and provided 2022 outlook.

Key Takeaways

AlloVir reported its full-year 2021 financial results, highlighting advancements in its clinical development programs, including three Phase 3 registrational studies for posoleucel. The company also reported a strong cash position with $248.1 million at year-end.

Three ongoing Phase 3 registrational studies of posoleucel are expected in 2022, targeting treatment and prevention indications.

Enrollment expanded in Phase 2 proof-of-concept study of posoleucel for BK viremia in kidney transplant recipients.

Two additional virus-specific T cell therapies are advancing: ALVR106 for respiratory viral infections and ALVR107 for hepatitis B cure.

Cash and cash equivalents totaled $248.1 million at year-end 2021.

EPS
-$0.92
Previous year: -$1.27
-27.6%
Cash and Equivalents
$248M
Previous year: $356M
-30.4%
Free Cash Flow
-$27.7M
Total Assets
$287M
Previous year: $371M
-22.7%

Allovir

Allovir

Forward Guidance

AlloVir anticipates key milestones in 2022, including the advancement of posoleucel through Phase 3 trials and the continued development of its VST therapies.

Positive Outlook

  • Global enrollment is ongoing in registrational studies of posoleucel for the treatment of virus-associated HC.
  • Global enrollment is ongoing in registrational studies of posoleucel for the treatment of AdV infections.
  • A Phase 3 registrational trial for multi-virus prevention is expected to initiate in the first half of this year.
  • Initial data from the ongoing posoleucel POC study for BKV treatment in KT recipients expected in the first half of 2022.
  • Preclinical and IND-enabling studies of ALVR107 to treat and cure hepatitis B will be completed in 2022.