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Jun 30, 2022

Annexon Q2 2022 Earnings Report

Annexon reported second quarter 2022 financial results and outlined progress across its broad pipeline.

Key Takeaways

Annexon reported a net loss of $37.1 million, or $0.96 per share, for the quarter ended June 30, 2022. The company's cash and cash equivalents were $177.6 million as of June 30, 2022, and with the proceeds from a recent financing, they expect to fund operations into the second half of 2025.

Phase 1 clinical trials initiated for ANX1502 and ANX105.

FDA granted Fast Track designation to ANX007 for geographic atrophy (GA).

Final data from Phase 2 clinical trial of ANX005 demonstrated upstream classical complement inhibition associated with clinical benefit in Huntington’s Disease.

Operating runway extended into the second half of 2025 following $130 million private placement.

EPS
-$0.96
Previous year: -$0.82
+17.1%
Cash and Equivalents
$178M
Previous year: $302M
-41.3%
Free Cash Flow
-$29M
Previous year: -$24.6M
+17.8%
Total Assets
$221M
Previous year: $332M
-33.5%

Annexon

Annexon

Forward Guidance

Annexon anticipates several potential catalysts across its pipeline throughout 2022 and 2023.

Positive Outlook

  • Initial data from its ongoing Phase 2 trial in patients with wAIHA in the second half of 2022
  • Data from its ongoing Phase 2/3 trial in patients with GBS in 2023
  • Data from its ongoing Phase 2 trial in patients with ALS in 2023
  • Initial data from its ongoing Phase 2 trial in patients with GA in the first half of 2023, with additional data after the conclusion of the six-month off-treatment period in the second half of 2023
  • Initial data from its Phase 1b trial in patients with lupus nephritis in the second half of 2022, with full data in 2023

Challenges Ahead

  • First-in-human data from its ongoing Phase 1 trial of ANX1502 in 2023
  • First-in-human data from its ongoing Phase 1 trial of ANX105 in 2023