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CRISPR Therapeutics
🇨🇭 NASDAQ:CRSP
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Jun 30, 2021

CRISPR Therapeutics Q2 2021 Earnings Report

Reported notable data from hemoglobinopathies program while rapidly advancing clinical and pre-clinical portfolio and capabilities.

Key Takeaways

CRISPR Therapeutics reported a strong second quarter, highlighted by a $900 million upfront payment from Vertex related to their collaboration agreement. The company is progressing its clinical programs, including CTX001 for hemoglobinopathies, and anticipates reporting clinical data from immuno-oncology programs later in the year.

More than 45 patients have been dosed with CTX001 across CLIMB-Thal-111 and CLIMB-SCD-121 to date; completion of enrollment in both trials is expected in 2021

Received Orphan Drug Designation (ODD) for Phase 1 clinical trial of CTX130â„¢ for the treatment of T-cell lymphoma

Enrollment ongoing in CTX110â„¢, CTX120â„¢ and CTX130 clinical trials

Vertex made a $900 million upfront payment to CRISPR Therapeutics in connection with the completion of the transaction in June

Total Revenue
$901M
Previous year: $44K
+2046947.7%
EPS
$9.44
Previous year: -$1.3
-826.2%
Gross Profit
$873M
Previous year: -$59.3M
-1571.7%
Cash and Equivalents
$1.65B
Previous year: $945M
+74.2%
Free Cash Flow
$779M
Previous year: -$32.9M
-2467.6%
Total Assets
$2.9B
Previous year: $1.05B
+177.1%

CRISPR Therapeutics

CRISPR Therapeutics

CRISPR Therapeutics Revenue by Segment

Forward Guidance

The Company expects to report additional clinical data in 2021 from its ongoing Phase 1 CARBON trial assessing the safety and efficacy of several dose levels of CTX110, its wholly-owned allogeneic chimeric antigen receptor T cell (CAR-T) investigational therapy targeting CD19, for the treatment of relapsed or refractory B-cell malignancies. The Company expects to report top-line data from CTX120 and CTX130 trials in 2021.

Positive Outlook

  • Expects to report additional clinical data in 2021 from its ongoing Phase 1 CARBON trial assessing the safety and efficacy of several dose levels of CTX110
  • CRISPR Therapeutics’ Phase 1 clinical trial assessing the safety and efficacy of several dose levels of CTX120 is ongoing and expects to report top-line data from this trial in 2021
  • CRISPR Therapeutics’ two independent Phase 1 clinical trials assessing the safety and efficacy of several dose levels of CTX130 are ongoing and expects to report top-line data from these trials in 2021
  • CRISPR Therapeutics and its partner ViaCyte remain on track to initiate a Phase 1/2 trial of their allogeneic stem cell-derived therapy for the treatment of Type 1 diabetes in 2021
  • The Company expects to move multiple programs utilizing in vivo approaches into the clinic in the next 18 to 24 months

Company Overview

Full financial data and analysis

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