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Sep 30, 2022

Design Therapeutics Q3 2022 Earnings Report

Highlighted pipeline progress, upcoming milestones, and reported third quarter 2022 financial results.

Key Takeaways

Design Therapeutics reported its Q3 2022 financial results, highlighting the progress of its Phase 1 clinical program for DT-216, which is on track for initial data reporting in December 2022, and the initiation of dosing in the multiple-ascending dose trial. The company's financial position remains strong with $344.2 million in cash and securities.

Initial data from the single-ascending dose Phase 1 trial of DT-216 for Friedreich Ataxia is expected in December 2022.

Dosing has commenced in the multiple-ascending dose Phase 1 trial of DT-216, with trial completion anticipated in mid-2023.

Preclinical data supporting DT-216 for the treatment of FA was presented at ICAR.

The company has a strong financial position with $344.2 million in cash and securities.

EPS
-$0.32
Previous year: -$0.21
+52.4%
Cash and Equivalents
$344M
Previous year: $394M
-12.6%
Free Cash Flow
-$14.2M
Previous year: -$9.13M
+55.6%
Total Assets
$355M
Previous year: $400M
-11.4%

Design Therapeutics

Design Therapeutics

Forward Guidance

Design Therapeutics is focused on advancing its GeneTAC™ platform and pipeline, with key milestones expected in the near term. The company anticipates clinical development for its DM1 program in 2023 and continued preclinical research in FECD.

Positive Outlook

  • Initial data from Single-Ascending Dose Phase 1 Trial for DT-216 is on-track to be reported in December 2022.
  • Dosing has been initiated in Multiple-Ascending Dose Phase 1 Trial for DT-216.
  • Clinical Development for DM1 Program is anticipated in 2023.
  • Continued Advancement in Research for FECD.
  • The company believes its approach paves the way for disease-modifying treatments for patients with inherited genetic diseases.

Challenges Ahead

  • Clinical trial and patient enrollment risks may affect the ongoing Phase 1 clinical trials for DT-216.
  • The risk that promising early research or clinical trials do not demonstrate safety and/or efficacy in later preclinical studies or clinical trials.
  • Uncertainties associated with performing clinical trials, regulatory filings and applications.
  • Reliance on third parties to successfully conduct clinical trials and preclinical studies.
  • Competition in the industry may result in others discovering, developing or commercializing competitive products before or more successfully than Design.