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Mar 31

Guardant Health Q1 2025 Earnings Report

reported financial results for the first quarter ended March 31, 2025

Key Takeaways

Guardant Health reported strong revenue growth of 21% in Q1 2025, driven by solid performance in oncology, screening, and biopharma & data segments. The company also increased its full-year 2025 revenue guidance.

Total revenue increased 21% to $203.5 million compared to the prior year period.

Oncology revenue grew 20% to $150.6 million, with a 25% increase in oncology test volume.

Screening revenue was $5.7 million, generated from approximately 9,000 Shield screening tests.

Biopharma & Data revenue increased 21% to $45.4 million.

Total Revenue
$203M
Previous year: $168M
+20.8%
EPS
-$0.49
Previous year: -$0.46
+6.5%
Oncology tests volume
59K
Shield screening tests volume
9K
Guardant360 ASP
$3.05K
Gross Profit
$129M
Previous year: $103M
+24.8%
Cash and Equivalents
$699M
Previous year: $1.13B
-38.1%
Free Cash Flow
-$67.1M
Previous year: -$37.2M
+80.5%
Total Assets
$1.34B
Previous year: $1.7B
-21.1%

Guardant Health

Guardant Health

Guardant Health Revenue by Segment

Forward Guidance

Guardant Health raised its full-year 2025 revenue guidance and provided updated expectations for oncology, screening, and biopharma & data revenue growth.

Positive Outlook

  • Full year 2025 revenue guidance raised to $880 to $890 million, representing 19% to 20% growth.
  • Oncology revenue expected to grow approximately 18% year over year in 2025.
  • Oncology volume expected to accelerate to greater than 25% growth in 2025.
  • Screening revenue expected in the range of $40 to $45 million, driven by Shield volume of 52,000 to 58,000 tests.
  • Free cash flow burn expected to improve to $225 to $235 million for the full year 2025.

Challenges Ahead

  • Total non-GAAP operating expenses expected to increase to $830 to $840 million.
  • The increase in non-GAAP operating expenses is due to reinvestment of incremental Screening gross profit to accelerate commercial infrastructure build out.
  • Free cash flow burn includes approximately $200 million of screening net cash burn.

Revenue & Expenses

Visualization of income flow from segment revenue to net income