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Mar 31, 2021

Ionis Q1 2021 Earnings Report

Ionis reported financial results for Q1 2021, highlighting progress in maximizing the value of its wholly owned pipeline and strengthening its balance sheet.

Key Takeaways

Ionis Pharmaceuticals reported $112 million in total revenues for Q1 2021. The company has strengthened its balance sheet with a pro forma cash of $2.1 billion. They are on track to achieve their 2021 financial guidance, reflecting investments in Ionis’ wholly owned pipeline.

Total revenues reached $112 million.

Operating expenses were $159 million on a non-GAAP basis and $204 million on a GAAP basis.

Net loss was $45 million on a non-GAAP basis and $90 million on a GAAP basis.

Pro forma cash reached $2.1 billion after reflecting the convertible notes transaction.

Total Revenue
$112M
Previous year: $133M
-15.8%
EPS
-$0.32
Previous year: -$0.35
-8.6%
Gross Profit
$109M
Previous year: $131M
-16.7%
Cash and Equivalents
$1.82B
Previous year: $2.38B
-23.7%
Free Cash Flow
-$56.4M
Previous year: -$16.7M
+238.5%
Total Assets
$2.25B
Previous year: $3.09B
-27.2%

Ionis

Ionis

Ionis Revenue by Segment

Forward Guidance

Ionis is on track to achieve its 2021 financial guidance and expects R&D revenue to increase in the second half of the year.

Positive Outlook

  • On track to achieve 2021 financial guidance.
  • Expect R&D revenue to increase in the second half of 2021.
  • Well-capitalized with resources to expand manufacturing and R&D capacity.
  • Completing restructuring of European operations and expanded Sobi distribution agreement to include North America.
  • Redirecting resources towards highest priority programs, including IONIS-TTR-LRx and IONIS-APOCIII-LRx.

Challenges Ahead

  • Operating expenses increased due to investments in the late-stage wholly owned pipeline.
  • Net loss attributable to Ionis common stockholders increased compared to the same period in the prior year.
  • Incurred $7 million of costs related to the Akcea acquisition and restructured European operations.
  • Expect to incur additional expenses in the range of $11 million to $14 million related to the restructuring of its North American TEGSEDI operations.
  • R&D revenue decreased compared to the same period last year due to fewer milestone payments.

Revenue & Expenses

Visualization of income flow from segment revenue to net income