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Jun 30, 2023

Protagonist Q2 2023 Earnings Report

Protagonist reported positive topline results from the Phase 2b FRONTIER 1 study of JNJ-2113 and made strides in the clinical development of rusfertide in polycythemia vera.

Key Takeaways

Protagonist Therapeutics reported positive data from the FRONTIER 1 and REVIVE studies, with JNJ-2113 advancing to Phase 3 and rusfertide's Phase 3 VERIFY study continuing. The company's cash position is strong, with runway through the end of 2025.

Positive topline results from the Phase 2b FRONTIER 1 study of JNJ-2113 were presented at the World Congress of Dermatology.

JNJ-2113 is advancing toward a Phase 3 study in psoriasis and a Phase 2b study in ulcerative colitis.

Positive data from the Phase 2 REVIVE study of rusfertide in polycythemia vera were presented at the European Hematology Association (EHA2023).

The global Phase 3 VERIFY study of rusfertide is ongoing, with enrollment completion projected by the end of the first quarter of 2024.

EPS
-$0.68
Previous year: -$0.84
-19.0%
Cash and Equivalents
$0
Previous year: $120M
-100.0%
Free Cash Flow
-$26.4M
Previous year: -$13.9M
+89.7%
Total Assets
$320M
Previous year: $311M
+3.2%

Protagonist

Protagonist

Forward Guidance

Protagonist anticipates continued progress in the clinical development of JNJ-2113 and rusfertide, with potential milestone payments and a strong cash runway.

Positive Outlook

  • Potential benefits of JNJ-2113
  • Expectations regarding the clinical development of JNJ-2113
  • Potential receipt of milestone and royalty payments under collaboration agreement with Janssen Biotech, Inc.
  • Forecasted cash runway
  • Expectations regarding enrollment in the REVIVE Phase 3 trial

Challenges Ahead

  • Ability to develop and commercialize product candidates
  • Ability to earn milestone payments under collaboration agreement with Janssen Biotech, Inc.
  • Ability to use and expand programs to build a pipeline of product candidates
  • Ability to obtain and maintain regulatory approval of product candidates
  • Ability to operate in a competitive industry and compete successfully against competitors that have greater resources