SpringWorks Therapeutics executed well in Q2 2021, advancing the nirogacestat strategy, extending mirdametinib patent protection, and expanding the oncology pipeline.
Entered into a clinical collaboration with Seagen to evaluate Nirogacestat in combination with SEA-BCMA.
Announced the issuance of a new U.S. composition of matter patent to a polymorphic form of Mirdametinib, extending patent protection into 2041.
Announced several new clinical trials for Mirdametinib, including a Phase 1/2 trial in children and young adults with low-grade glioma and a Phase 1b/2a trial in patients with advanced solid cancers harboring selected MAPK-activating mutations.
Expanded the targeted oncology pipeline with an exclusive worldwide license to the TEA Domain (TEAD) Inhibitor Portfolio.
The company expects important data readouts across its late-stage rare oncology, BCMA combinations in multiple myeloma and metastatic solid tumor programs, including topline data from the Phase 3 DeFi study, and will continue to advance its 15 development programs.