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Sep 30, 2022

Spyre Q3 2022 Earnings Report

Aeglea BioTherapeutics reported financial results for the third quarter ended September 30, 2022 and provided program updates.

Key Takeaways

Aeglea BioTherapeutics reported $75.2 million in cash as of September 30, 2022. The company recognized development fee revenues of $0.2 million in the third quarter of 2022. Research and development expenses totaled $12.0 million and general and administrative expenses totaled $7.0 million for the third quarter of 2022. Net loss totaled $18.2 million for the third quarter of 2022.

Prioritized pegtarviliase program to optimize resources and maximize success.

Ongoing enrollment of cohort 3 in Phase 1/2 trial of pegtarviliase for Classical Homocystinuria.

Marketing Authorization Application for pegzilarginase for Arginase 1 Deficiency submitted by Immedica is under review by the EMA.

Corporate restructuring announced to prioritize resources and focus on the pegtarviliase program while reducing expenses.

Total Revenue
$174K
Previous year: $1.4M
-87.6%
EPS
-$4.75
Previous year: -$7.75
-38.7%
Cash Runway
1.25
Gross Profit
$174K
Previous year: $1.4M
-87.6%
Cash and Equivalents
$39M
Previous year: $24.7M
+58.1%
Free Cash Flow
-$15.1M
Previous year: -$17.1M
-11.8%
Total Assets
$91.6M
Previous year: $129M
-29.1%

Spyre

Spyre

Spyre Revenue by Segment

Forward Guidance

Aeglea expects its cash, cash equivalents and marketable securities will enable it to fund its operating expenses and capital expenditure requirements into the fourth quarter of 2023.