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Wave Life Sciences Q1 2025 Earnings Report
Wave Life Sciences reported its first quarter 2025 financial results with a decrease in revenue and an increase in net loss compared to the prior year.
Key Takeaways
Wave Life Sciences reported a net loss of $46.878 million for the first quarter of 2025, compared to a net loss of $31.558 million in the prior year quarter. Revenue decreased to $9.175 million from $12.538 million in the same period last year. The company ended the quarter with $243.075 million in cash and cash equivalents, with a runway expected into 2027.
Dosing completed in the first two cohorts of INLIGHT trial for WVE-007 in obesity, with clinical data expected in 2H 2025.
Dosing underway in RestorAATion-2 clinical trial for WVE-006, with data from complete 200 mg multidose and single dose cohorts expected in 3Q 2025.
Positive data delivered from FORWARD-53 clinical trial for WVE-N531 in DMD, with NDA submission planned for 2026.
IND submission expected 2H 2025 for potentially registrational WVE-003 Phase 2/3 study in HD.
Forward Guidance
Wave Life Sciences expects to deliver multiple clinical datasets in 2025, including clinical data from INLIGHT in 2H 2025, and data from RestorAATion-2 in 3Q 2025 and Fall 2025. The company also plans for NDA submission for WVE-N531 in 2026 and IND submission for WVE-003 in 2H 2025.
Positive Outlook
- Clinical data from INLIGHT trial (WVE-007) in obesity expected in 2H 2025.
- Data from complete 200 mg multidose and single dose cohorts of RestorAATion-2 (WVE-006) expected in 3Q 2025.
- Data from complete 400 mg single dose cohort of RestorAATion-2 (WVE-006) expected in Fall 2025.
- NDA submission for accelerated approval of WVE-N531 in DMD planned for 2026.
- IND submission for potentially registrational WVE-003 Phase 2/3 study in HD expected in 2H 2025.
Challenges Ahead
- No specific negative forward guidance was provided in the report.
- No specific negative forward guidance was provided in the report.
- No specific negative forward guidance was provided in the report.
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