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Dec 31, 2024
Acumen Q4 2024 Earnings Report
Acumen reported a larger net loss in Q4 2024 as R&D expenses ramped up to support its Phase 2 Alzheimer’s trial.
Key Takeaways
Acumen posted a $37.1M net loss in Q4 2024, driven by increased R&D spending on its ALTITUDE-AD trial. The company did not generate revenue and remains focused on its Alzheimer’s pipeline.
Net loss reached $37.1M in Q4 with no revenue generated.
R&D expenses surged to $27.2M due to the ongoing Phase 2 trial.
Cash and equivalents at quarter-end totaled $33.18M.
Topline data for the ALTITUDE-AD trial expected in late 2026.
Forward Guidance
Acumen expects to complete enrollment for its Phase 2 Alzheimer’s trial in 1H 2025 and projects sufficient funding into 1H 2027.
Positive Outlook
- Enrollment for ALTITUDE-AD progressing on track.
- Topline data expected in late 2026.
- Strong cash position expected to fund operations into 2027.
- Clear focus on advancing sabirnetug in Alzheimer’s treatment.
- Strategic collaborations supporting subcutaneous formulation development.
Challenges Ahead
- No revenue generation expected in the near term.
- High R&D spending driving ongoing operating losses.
- Dependence on future fundraising or partnerships.
- Trial completion and data readout still more than a year away.
Historical Earnings Impact
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Avg. Return Before/After Earnings
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