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Dec 30, 2024
Adicet Bio Q4 2024 Earnings Report
Adicet Bio reported its financial results for the fourth quarter and full year ended December 31, 2024, highlighting ongoing clinical trial progress for autoimmune diseases and cancer treatments.
Key Takeaways
Adicet Bio reported a net loss of $28.7 million for Q4 2024, an improvement from a $29.5 million net loss in Q4 2023. The company's cash position increased to $176.3 million, and it expects current funds to last into the second half of 2026. R&D expenses decreased, while G&A expenses saw a slight increase.
Net loss for Q4 2024 was $28.7 million, an improvement from $29.5 million in Q4 2023.
Cash, cash equivalents, and short-term investments totaled $176.3 million as of December 31, 2024, up from $159.7 million in 2023.
Research and Development (R&D) expenses decreased to $23.3 million in Q4 2024 from $24.8 million in Q4 2023, primarily due to lower CDMO expenses.
General and Administrative (G&A) expenses increased to $7.5 million in Q4 2024 from $6.8 million in Q4 2023, mainly due to higher professional fees.
Forward Guidance
Adicet Bio plans to continue advancing its gamma delta 1 CAR T cell therapy programs in 2025, with key milestones including preliminary data reports for autoimmune and oncology indications. The company expects its current cash, cash equivalents, and short-term investments to fund operating expenses into the second half of 2026.
Positive Outlook
- Preliminary clinical data from lupus nephritis (LN) patient cohort expected in 1H25.
- Additional LN clinical data and preliminary clinical data from other autoimmune patient cohorts anticipated in 2H25.
- Initiation of ADI-001 Phase 1 clinical trial patient enrollment in SLE, SSc, IIM, and SPS expected in 2Q25.
- Advancing patient enrollment in ADI-270 Phase 1 clinical trial in patients with metastatic/advanced clear cell renal cell carcinoma (ccRCC), with preliminary data expected in 1H25.
- Current cash, cash equivalents, and short-term investments are sufficient to fund operating expenses into the second half of 2026.
Challenges Ahead
- AAV patient enrollment expected to be initiated in 2H25, later than other autoimmune cohorts.
- Additional LN clinical data and preliminary clinical data from other autoimmune patient cohorts in 2H25 are subject to study site initiation and patient enrollment.
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