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Jun 30, 2025
ALX Oncology Q2 2025 Earnings Report
ALX Oncology reported its financial results for the second quarter of 2025, highlighting advancements in its clinical programs and an extended cash runway.
Key Takeaways
ALX Oncology reported a reduced GAAP net loss of $25.9 million for Q2 2025, down from $39.4 million in the prior year, primarily due to lower R&D expenses. The company also extended its cash runway into Q1 2027 and made significant progress in its evorpacept and ALX2004 clinical programs.
GAAP net loss for Q2 2025 was $25.9 million, a significant improvement from $39.4 million in Q2 2024.
Research and Development (R&D) expenses decreased by $16.6 million to $18.0 million in Q2 2025, driven by reduced clinical and development costs, stock-based compensation, and personnel costs.
The company extended its cash runway into Q1 2027 through strategic prioritization of its development programs.
Key clinical milestones include updated ASPEN-Breast trial design with anticipated interim data in Q3 2026 and ALX2004 Phase 1 trial dosing expected in August 2025.
Forward Guidance
ALX Oncology anticipates significant clinical milestones in 2026 for its evorpacept and ALX2004 programs, with a cash runway extended into Q1 2027.
Positive Outlook
- Cash runway extended into Q1 2027, providing financial stability for upcoming milestones.
- Interim data from the ASPEN-Breast trial anticipated in Q3 2026, potentially supporting a biomarker-driven registrational study.
- First patient dosing for the ALX2004 Phase 1 clinical trial is anticipated in August 2025, with initial safety data expected in 1H 2026.
- Updated ASPEN-Breast trial design is expected to optimize enrollment and further evaluate CD47 as a predictive biomarker.
- ALX2004 has best-in-class potential for EGFR-expressing solid tumors with a potentially differentiated safety profile.
Challenges Ahead
- Paused ASPEN-CRC study in colorectal cancer to extend cash runway, indicating a narrowing of development focus.
- No specific revenue guidance provided, typical for a clinical-stage biotechnology company.
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