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Dec 31, 2025
OraSure Q4 2025 Earnings Report
OraSure Technologies reported its fourth quarter 2025 financial results, showing a decline in revenue but exceeding the midpoint of its guidance range.
Key Takeaways
OraSure faced a challenging 2025 with a 29% year-over-year revenue decline in Q4, primarily driven by lower HIV test sales and a drop in consumer genomics demand. Despite the revenue contraction and a significant operating loss, the company maintained a strong cash position of $199 million and is pivoting toward growth in 2026 through new FDA submissions for STI testing and molecular self-tests.
Q4 total revenue of $26.8 million exceeded the midpoint of management's guidance despite a 29% year-over-year decrease.
Core business revenue fell 22% to $26.7 million, impacted by lower HIV test volumes and a large customer decline in Sample Management Solutions.
The company submitted two major FDA applications in December 2025 for a rapid molecular CT/NG self-test and the Colli-Pee™ at-home collection device.
OraSure continues to execute its $40 million share repurchase program, deploying $5 million to buy back 1.9 million shares during the quarter.
Revenue by Segment
Forward Guidance
OraSure expects Q1 2026 total revenues to be between $26 million and $29 million, with a focus on returning to growth throughout the year.
Positive Outlook
- Anticipated U.S. regulatory clearance for rapid molecular CT/NG self-test.
- Expected launch of Colli-Pee™ at-home urine collection device for STIs.
- Increasing signs of stability in key market segments entering 2026.
- Strong balance sheet with $199 million in cash to fund organic and inorganic growth.
- New license from Health Canada for OraQuick™ HIV Self-Test.
Challenges Ahead
- Q1 2026 guidance includes a negligible amount of COVID-19 testing revenue.
- Challenging funding environment for customers persisted through 2025.
- Significant decline in consumer genomics segment impacting Sample Management.
- Ongoing GAAP and Non-GAAP operating losses.
Revenue & Expenses
Visualization of income flow from segment revenue to net income
Historical Earnings Impact
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Avg. Return Before/After Earnings
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