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Mar 31, 2025
Repare Therapeutics Q1 2025 Earnings Report
Repare Therapeutics Inc. reported a net loss for Q1 2025, primarily due to a significant decrease in collaboration revenue following the termination of a key agreement.
Key Takeaways
Repare Therapeutics Inc. experienced a net loss of $30.043 million in the first quarter of 2025, a substantial decline from a net income of $13.162 million in the same period last year. This was largely driven by the absence of collaboration revenue, which was $52.404 million in Q1 2024, following the termination of the Roche Agreement. Operating expenses also decreased, primarily due to strategic re-prioritization and workforce reductions.
Net loss of $30.043 million in Q1 2025, compared to net income of $13.162 million in Q1 2024.
Total revenue was nil in Q1 2025, a significant decrease from $52.404 million in Q1 2024 due to the termination of the Roche Agreement.
Research and development expenses decreased by $12.7 million to $20.270 million in Q1 2025, reflecting strategic re-prioritization and workforce reductions.
The company had cash and cash equivalents and marketable securities of $124.2 million as of March 31, 2025, and anticipates these funds will be sufficient to cover operating and capital expenditure requirements through 2027.
Forward Guidance
Repare Therapeutics Inc. anticipates continued significant expenses and operating losses as it advances its product candidates through preclinical and clinical development and seeks regulatory approvals. The company expects its current cash and cash equivalents to be sufficient to fund operations through 2027, following strategic re-prioritization and workforce reductions.
Positive Outlook
- Sufficient cash and cash equivalents to fund anticipated operating and capital expenditure requirements through 2027.
- Strategic re-prioritization to focus on advancing clinical-stage oncology programs (RP-3467 and RP-1664).
- Out-licensing of early-stage discovery platforms to DCx Biotherapeutics Corporation, including upfront and near-term payments, equity position, and potential future milestone payments and royalties.
- Exploration of strategic alternatives and partnerships across the portfolio to maximize shareholder value.
- Anticipated topline safety, tolerability, and early efficacy data from the POLAR trial (RP-3467) in Q3-2025.
Challenges Ahead
- Expectation of continued significant expenses and operating losses for the foreseeable future.
Historical Earnings Impact
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