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Dec 31, 2025
Syndax Q4 2025 Earnings Report
Syndax reported strong fourth quarter 2025 revenue growth driven by Revuforj and Niktimvo, while continuing to incur a net loss amid increased operating expenses.
Key Takeaways
In Q4 2025, Syndax generated $68728000 in total revenue, primarily from Revuforj and Niktimvo, but reported a net loss of $68014000 as R&D and SG&A expenses increased year-over-year.
Total revenue reached 68728000 in Q4 2025, driven by product and collaboration revenue.
Revuforj net revenue was 44195000, reflecting continued commercial uptake.
Niktimvo collaboration revenue contributed 19392000 in the quarter.
Net loss narrowed year-over-year to 68014000 despite higher operating expenses.
Revenue by Segment
Forward Guidance
For full year 2026, Syndax expects total R&D plus SG&A expenses to be approximately 400000000, excluding an estimated 50000000 in non-cash stock compensation expense.
Positive Outlook
- Expected total R&D plus SG&A expenses of approximately 400000000 in 2026.
- Excludes approximately 50000000 in estimated non-cash stock compensation expense.
- Operating expense base expected to remain stable over the next couple of years.
- Anticipated product and collaboration revenue to support operations.
- Cash position expected to help enable path to profitability.
Challenges Ahead
- Guidance excludes 50000000 in non-cash stock compensation expense.
- Continued high operating expense base.
- Ongoing net losses.
- Dependence on commercial uptake of products.
Revenue & Expenses
Visualization of income flow from segment revenue to net income
Historical Earnings Impact
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Avg. Return Before/After Earnings
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