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Dec 31, 2021

Ionis Q4 2021 Earnings Report

Ionis Pharmaceuticals reported financial results for the fourth quarter and full year ended December 31, 2021, and recent business achievements.

Key Takeaways

Ionis Pharmaceuticals exceeded its 2021 financial guidance with revenues of $810 million. The company is well capitalized with $2.1 billion in cash and short-term investments at year-end. They are advancing their commercial strategy and go-to-market plans for near-term commercial opportunities.

Ionis exceeded 2021 financial guidance with revenues of more than $800 million.

A collaboration with AstraZeneca was initiated to jointly develop and commercialize eplontersen.

Phase 3 studies with olezarsen in patients with severely high triglycerides and donidalorsen in patients with hereditary angioedema were initiated.

Biogen licensed ION306 (BIIB115) for the treatment of SMA with the potential for extended dosing intervals, resulting in a $60 million payment from Biogen.

Total Revenue
$440M
Previous year: $290M
+51.7%
EPS
$1.55
Previous year: $0.81
+91.4%
Gross Profit
$438M
Previous year: $287M
+52.6%
Cash and Equivalents
$2.12B
Previous year: $1.89B
+11.8%
Free Cash Flow
$201M
Previous year: $92.8M
+116.7%
Total Assets
$2.61B
Previous year: $2.39B
+9.3%

Ionis

Ionis

Ionis Revenue by Segment

Forward Guidance

Ionis provided full year 2022 financial guidance on a non-GAAP basis. They anticipate revenue greater than $575 million, operating expenses between $825 million and $850 million, a net loss less than $275 million, and cash and short-term investments around $1.7 billion.

Revenue & Expenses

Visualization of income flow from segment revenue to net income